© Oxford University Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside. en-GB Tue, 07 May 2013 16:14:01 +0100 http://www.ndm.ox.ac.uk/ Oxford University http://media.podcasts.ox.ac.uk/clmed/translational/translational-medicine-ac.jpg http://www.ndm.ox.ac.uk/ vaccines malaria Jenner Institute clinical trials Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle Malaria transmission-blocking vaccines aim to induce immunity against the parasites that infect mosquitoes. Such vaccines will prevent malaria transmission on a wider scale, focusing on the community rather than the individual. Dr Sumi Biswas is working on the development of transmission-blocking vaccines to prevent the spread of malaria. http://rss.oucs.ox.ac.uk/tag:2013-05-07:152744:212:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/2013-4-25-clmed-biswas.mp4?CAMEFROM=podcastsRSS Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle Malaria transmission-blocking vaccines aim to induce immunity against the parasites that infect mosquitoes. Such vaccines will prevent malaria transmission on a wider scale, focusing on the community rather than the individual. Dr Sumi Biswas is working on the development of transmission-blocking vaccines to prevent the spread of malaria. vaccines,malaria,Jenner Institute,clinical trials Sumi Biswas 103 470 Tue, 07 May 2013 15:27:44 +0100 Translational Medicine gastroenterology clinical trials ulcerative colitis Crohn's disease outcomes research Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today Before translating basic research into the clinic it is important first to undergo clinical trials in order to identify safe treatments and therapies for disease. Led by Dr Simon Travis the Gastroenterology Clinical Trials Facility at Oxford University works to translate basic research into clinical trials of novel therapies for gastrointestinal and liver diseases. http://rss.oucs.ox.ac.uk/tag:2013-03-25:171116:050:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/2013-01-24_transmed_simon.mp4?CAMEFROM=podcastsRSS Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today Before translating basic research into the clinic it is important first to undergo clinical trials in order to identify safe treatments and therapies for disease. Led by Dr Simon Travis the Gastroenterology Clinical Trials Facility at Oxford University works to translate basic research into clinical trials of novel therapies for gastrointestinal and liver diseases. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ gastroenterology,clinical trials,ulcerative colitis,Crohn's disease,outcomes research Simon Travis 103 251 Mon, 25 Mar 2013 17:11:16 +0000 Translational Medicine cancer immunotherapy vaccines T cell tumour immunology adjuvants Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. http://rss.oucs.ox.ac.uk/tag:2013-03-25:150120:506:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/2013-01-24_transmed_enzo.mp4?CAMEFROM=podcastsRSS Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ cancer,immunotherapy,vaccines,T cell,tumour immunology,adjuvants Vincenzo Cerundolo 103 453 Mon, 25 Mar 2013 15:01:20 +0000 Translational Medicine Cancer regenerative medicine reprogramming oncogene tumour suppressor Professor Xin Lu talks about the links between cancer and regenerative medicine Professor Xin Lu is the Director of the Oxford branch of the Ludwig Institute for Cancer Research. Her lab works toward identifying molecular mechanisms that suppress tumour growth and metastasis and focuses on understanding the factors that lead to uncontrollable cell growth. http://rss.oucs.ox.ac.uk/tag:2013-03-22:145918:342:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/xin_lu.mp4?CAMEFROM=podcastsRSS Professor Xin Lu talks about the links between cancer and regenerative medicine Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Xin Lu talks about the links between cancer and regenerative medicine Professor Xin Lu is the Director of the Oxford branch of the Ludwig Institute for Cancer Research. Her lab works toward identifying molecular mechanisms that suppress tumour growth and metastasis and focuses on understanding the factors that lead to uncontrollable cell growth. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Cancer,regenerative medicine,reprogramming,oncogene,tumour suppressor Xin Lu 103 259 Fri, 22 Mar 2013 14:59:18 +0000 Translational Medicine Innate immune system flu influenza Dr Jan Rehwinkel talks about the role of our innate immune system in our fight against flu virus Dr Jan Rehwinkel and his group study the bodys immune reaction to viruses such as flu and HIV 1 which affect millions of people worldwide. The aim is to impact on the management of infectious diseases and the development of vaccinations. This work also has an impact on auto-immune diseases such as Lupus. http://rss.oucs.ox.ac.uk/tag:2013-03-22:145132:084:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/2012-11-09-clmed-ndm-rehwinkel.mp4?CAMEFROM=podcastsRSS Dr Jan Rehwinkel talks about the role of our innate immune system in our fight against flu virus Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Jan Rehwinkel talks about the role of our innate immune system in our fight against flu virus Dr Jan Rehwinkel and his group study the bodys immune reaction to viruses such as flu and HIV 1 which affect millions of people worldwide. The aim is to impact on the management of infectious diseases and the development of vaccinations. This work also has an impact on auto-immune diseases such as Lupus. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Innate immune system,flu,influenza Jan Rehwinkel 103 452 Fri, 22 Mar 2013 14:51:32 +0000 Translational Medicine HIV Immune response vaccine eradication Dr John Frater talks about his research into finding a cure for HIV It is increasingly apparent that highly active antiretroviral therapy (HAART) may not be the long-term solution to the management of HIV infection, and that other avenues need to be explored. As a result of various recent cases, the idea of eradicating HIV altogether is becoming less unimaginable to some scientists. http://rss.oucs.ox.ac.uk/tag:2012-12-12:161519:462:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/john_frater.mp4?CAMEFROM=podcastsRSS Dr John Frater talks about his research into finding a cure for HIV Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr John Frater talks about his research into finding a cure for HIV It is increasingly apparent that highly active antiretroviral therapy (HAART) may not be the long-term solution to the management of HIV infection, and that other avenues need to be explored. As a result of various recent cases, the idea of eradicating HIV altogether is becoming less unimaginable to some scientists. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV,Immune response,vaccine,eradication Dr John Frater 103 379 Wed, 12 Dec 2012 16:15:19 +0000 Translational Medicine vaccine T cell immune response immunology malaria tuberculosis and influenza clinical trials Professor Sarah Gilbert talks about her work on viral vectored vaccines Professor Sarah Gilbert has been making and testing vaccines designed to induce T cell responses for ten years, chiefly using antigens from malaria and influenza. Based at the Jenner Institute, several of the vaccines developed in Professor Gilberts laboratory have progressed into Clinical Trials. http://rss.oucs.ox.ac.uk/tag:2012-11-14:135250:896:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/sarah_gilbert.mp4?CAMEFROM=podcastsRSS Professor Sarah Gilbert talks about her work on viral vectored vaccines Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Sarah Gilbert talks about her work on viral vectored vaccines Professor Sarah Gilbert has been making and testing vaccines designed to induce T cell responses for ten years, chiefly using antigens from malaria and influenza. Based at the Jenner Institute, several of the vaccines developed in Professor Gilberts laboratory have progressed into Clinical Trials. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ vaccine,T cell,immune response,immunology,malaria,tuberculosis and influenza,clinical trials Sarah Gilbert 103 238 Wed, 14 Nov 2012 13:52:50 +0000 Translational Medicine Multiple sclerosis MS neurodegenerative disease chronic inflammation central nervous system Professor Lars Fugger talks about his research on multiple sclerosis Professor Lars Fugger focuses on translational studies in multiple sclerosis and uses a multidisciplinary approach. He is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. Professor Fuggers group consists of both basic scientists and clinicians. http://rss.oucs.ox.ac.uk/tag:2012-10-30:141321:452:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/lars_fugger.mp4?CAMEFROM=podcastsRSS Professor Lars Fugger talks about his research on multiple sclerosis Professor Lars Fugger talks about his research on multiple sclerosis Professor Lars Fugger focuses on translational studies in multiple sclerosis and uses a multidisciplinary approach. He is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. Professor Fuggers group consists of both basic scientists and clinicians. Multiple sclerosis,MS,neurodegenerative disease,chronic inflammation,central nervous system Lars Fugger 103 248 Tue, 30 Oct 2012 14:13:21 +0000 Translational Medicine cancer colorectal cancer clinical trials epidemiology Dr Raghib Ali talks about INDOX, the cancer research network in India. Dr Raghib Ali is the Director of INDOX Cancer Research Network. His main interest is in colorectal (bowel) cancer and other chronic, non-communicable diseases. Incidence of colorectal cancer in India has been relatively low historically; understanding why may help us establish risk factors and also lead to new treatments. http://rss.oucs.ox.ac.uk/tag:2012-10-09:124739:589:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/raghib_ali.mp4?CAMEFROM=podcastsRSS Dr Raghib Ali talks about INDOX, the cancer research network in India. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Raghib Ali talks about INDOX, the cancer research network in India. Dr Raghib Ali is the Director of INDOX Cancer Research Network. His main interest is in colorectal (bowel) cancer and other chronic, non-communicable diseases. Incidence of colorectal cancer in India has been relatively low historically; understanding why may help us establish risk factors and also lead to new treatments. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ cancer,colorectal cancer,clinical trials,epidemiology Raghib Ali 103 236 Tue, 09 Oct 2012 12:47:39 +0100 Translational Medicine Epidemiology clinical trials malnutrition infection inflammation perinatal Dr Jay Berkley tells us about his work on childhood nutrition and immunity in East Africa Dr Jay Berkley works in the KEMRI/Wellcome Trust Collaborative Research Programme in Kilifi, Kenya. His research interests include tackling infection and inflammation to prevent mortality in malnourished children. He is also an expert advisor on severe acute malnutrition to the Ministries of Health, and the World Health Organisation. http://rss.oucs.ox.ac.uk/tag:2012-09-25:110236:117:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/jay_berkley.mp4?CAMEFROM=podcastsRSS Dr Jay Berkley tells us about his work on childhood nutrition and immunity in East Africa Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Jay Berkley tells us about his work on childhood nutrition and immunity in East Africa Dr Jay Berkley works in the KEMRI/Wellcome Trust Collaborative Research Programme in Kilifi, Kenya. His research interests include tackling infection and inflammation to prevent mortality in malnourished children. He is also an expert advisor on severe acute malnutrition to the Ministries of Health, and the World Health Organisation. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Epidemiology,clinical trials,malnutrition,infection,inflammation,perinatal Jay Berkley 103 436 Tue, 25 Sep 2012 11:02:36 +0100 Translational Medicine Inflammatory bowel disease intestinal inflammation paediatrics Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. Dr Holm Uhlig is based at the Translational Gastroenterology Unit and studies defects in the immune response and regulation leading to immunopathology. Dr Uhlig is interested in children with inflammatory bowel disease, and aims to understand the complex puzzle of molecular mechanisms involved. http://rss.oucs.ox.ac.uk/tag:2012-09-12:140035:454:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/holm_uhlig.mp4?CAMEFROM=podcastsRSS Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. Dr Holm Uhlig is based at the Translational Gastroenterology Unit and studies defects in the immune response and regulation leading to immunopathology. Dr Uhlig is interested in children with inflammatory bowel disease, and aims to understand the complex puzzle of molecular mechanisms involved. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Inflammatory bowel disease,intestinal inflammation,paediatrics Holm Uhlig 103 327 Wed, 12 Sep 2012 14:00:35 +0100 Translational Medicine Autoimmune diseases self tolerance adaptive immunity Professor Richard Cornall tells us about his research on autoimmunity. Professor Richard Cornall aims to understand the causes of autoimmune diseases. Autoimmunity occurs when the immune system which is normally designed to attack pathogens ends up attacking the body. Professor Cornall is also interested in how people differ in their inherited susceptibility and why these differences are sustained in human populations by natural selection. http://rss.oucs.ox.ac.uk/tag:2012-09-12:135712:700:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/richard_cornall.mp4?CAMEFROM=podcastsRSS Professor Richard Cornall tells us about his research on autoimmunity. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Richard Cornall tells us about his research on autoimmunity. Professor Richard Cornall aims to understand the causes of autoimmune diseases. Autoimmunity occurs when the immune system which is normally designed to attack pathogens ends up attacking the body. Professor Cornall is also interested in how people differ in their inherited susceptibility and why these differences are sustained in human populations by natural selection. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Autoimmune diseases,self tolerance,adaptive immunity Richard Cornall 103 536 Wed, 12 Sep 2012 13:57:12 +0100 Translational Medicine Malaria Vaccine Immunology Clinical Trials Dr Simon Draper tells us about his progress in malaria vaccine research. Dr Simon Draper's research interests include studies of vaccine induced malaria immunity. His group focuses on translational medicine. They will take their most promising vaccine candidates and manufacture them as clinical grade material. The next step is proof of concept clinical trials in healthy volunteers. http://rss.oucs.ox.ac.uk/tag:2012-09-11:105735:690:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/simon_draper.mp4?CAMEFROM=podcastsRSS Dr Simon Draper tells us about his progress in malaria vaccine research. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Simon Draper tells us about his progress in malaria vaccine research. Dr Simon Draper's research interests include studies of vaccine induced malaria immunity. His group focuses on translational medicine. They will take their most promising vaccine candidates and manufacture them as clinical grade material. The next step is proof of concept clinical trials in healthy volunteers. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Malaria,Vaccine,Immunology,Clinical Trials Simon Draper 103 398 Tue, 11 Sep 2012 10:57:35 +0100 Translational Medicine Rift Valley Fever vaccine development zoonosis Jenner Institute developing world neglected diseases Dr George Warimwe talks about his research on Rift Valley Fever. Dr George Warimwe is working with the International Livestock Research Institute (ILRI) A Centre of Excellence in Africa, and the Jenner Institute to develop a vaccine against Rift Valley Fever in humans, that will also be useful as a vaccination against the disease in livestock. http://rss.oucs.ox.ac.uk/tag:2012-08-08:170553:528:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/george_warimwe.mp4?CAMEFROM=podcastsRSS Dr George Warimwe talks about his research on Rift Valley Fever. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr George Warimwe talks about his research on Rift Valley Fever. Dr George Warimwe is working with the International Livestock Research Institute (ILRI) A Centre of Excellence in Africa, and the Jenner Institute to develop a vaccine against Rift Valley Fever in humans, that will also be useful as a vaccination against the disease in livestock. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Rift Valley Fever,vaccine development,zoonosis,Jenner Institute,developing world,neglected diseases George Warimwe 103 314 Tue, 31 Jul 2012 10:38:57 +0100 Translational Medicine Diabetes genetics insulin MODY clinical trials personalised treatment Dr Katharine Owen talks about the different types of Diabetes in young adults There are more forms of diabetes than the commonly known type 1 and type 2. Dr Katherine Owen investigates the different characteristics of monogenic diabetes with the aim of creating systematic diagnostics for aetiology of diabetes, and implementing that in clinical care. The ultimate aim is to promote personalized medicine for everybody with diabetes. http://rss.oucs.ox.ac.uk/tag:2012-07-17:114841:451:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/katharine_owen.mp4?CAMEFROM=podcastsRSS Dr Katharine Owen talks about the different types of Diabetes in young adults Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Katharine Owen talks about the different types of Diabetes in young adults There are more forms of diabetes than the commonly known type 1 and type 2. Dr Katherine Owen investigates the different characteristics of monogenic diabetes with the aim of creating systematic diagnostics for aetiology of diabetes, and implementing that in clinical care. The ultimate aim is to promote personalized medicine for everybody with diabetes. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Diabetes,genetics,insulin,MODY,clinical trials,personalised treatment Katherine Owen 103 313 Tue, 17 Jul 2012 11:48:41 +0100 Translational Medicine cancer metabolism fumarate hydratase hypoxia kidney renal cancer Dr Patrick Pollard tells us about his research on cancer metabolism Cancer cells produce energy predominately by a high rate of glycolysis. It has been suggested that this change in metabolism is a fundamental cause of cancer. Dr Patrick Pollard aims to elucidate the alternative metabolic strategies used by cancer cells to proliferate, even under conditions of stress. http://rss.oucs.ox.ac.uk/tag:2012-07-10:121235:001:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/patrick_pollard.mp4?CAMEFROM=podcastsRSS Dr Patrick Pollard tells us about his research on cancer metabolism Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Patrick Pollard tells us about his research on cancer metabolism Cancer cells produce energy predominately by a high rate of glycolysis. It has been suggested that this change in metabolism is a fundamental cause of cancer. Dr Patrick Pollard aims to elucidate the alternative metabolic strategies used by cancer cells to proliferate, even under conditions of stress. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ cancer metabolism,fumarate hydratase,hypoxia,kidney,renal cancer Patrick Pollard 103 243 Tue, 10 Jul 2012 12:12:35 +0100 Translational Medicine Diabetes Genetics Susceptibility-gene Genomics Biomarkers Statistical Genetics Professor Mark McCarthy tells us how genomics helps us understand diabetes. Professor Mark McCarthy (Robert Turner Professor of Diabetes) leads a multidisciplinary research team including clinicians, nurses and lab-based research staff. One of their major focuses lies in translating gene identification and genetic information into advances in functional understanding and clinical management. http://rss.oucs.ox.ac.uk/tag:2012-07-03:102048:721:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/mark_mccarthy.mp4?CAMEFROM=podcastsRSS Professor Mark McCarthy tells us how genomics helps us understand diabetes. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Mark McCarthy tells us how genomics helps us understand diabetes. Professor Mark McCarthy (Robert Turner Professor of Diabetes) leads a multidisciplinary research team including clinicians, nurses and lab-based research staff. One of their major focuses lies in translating gene identification and genetic information into advances in functional understanding and clinical management. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Diabetes,Genetics,Susceptibility-gene,Genomics,Biomarkers,Statistical Genetics Mark McCarthy 103 480 Tue, 03 Jul 2012 10:20:48 +0100 Translational Medicine Immunology Universal Flu Vaccine Influenza vaccine trials Dr Richard Antrobus talks about his research in the development of a universal flu vaccine Dr Antrobus has been conducting a Phase I study of a Universal Vaccine for Influenza. Progress so far indicates that this approach induces a potent T cell response, and Dr Antrobus is currently assessing whether this response is equally potent in the elderly - one of the 'at risk' groups of the Influenza virus. http://rss.oucs.ox.ac.uk/tag:2012-06-26:092234:563:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/richard_antrobus.mp4?CAMEFROM=podcastsRSS Dr Richard Antrobus talks about his research in the development of a universal flu vaccine Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Richard Antrobus talks about his research in the development of a universal flu vaccine Dr Antrobus has been conducting a Phase I study of a Universal Vaccine for Influenza. Progress so far indicates that this approach induces a potent T cell response, and Dr Antrobus is currently assessing whether this response is equally potent in the elderly - one of the 'at risk' groups of the Influenza virus. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Immunology,Universal Flu Vaccine,Influenza vaccine trials Richard Antrobus 103 397 Tue, 26 Jun 2012 09:22:34 +0100 Translational Medicine Plasmodium vivax malaria vaccines recombinant viral vectors Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year. http://rss.oucs.ox.ac.uk/tag:2012-06-19:112927:123:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/arturo_reyes-sandoval.mp4?CAMEFROM=podcastsRSS Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Plasmodium vivax,malaria vaccines,recombinant viral vectors Arturo Reyes-Sandoval 103 425 Tue, 19 Jun 2012 11:29:27 +0100 Translational Medicine ndm clinical medicine epidemiology cholesterol statin Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives http://rss.oucs.ox.ac.uk/tag:2012-06-18:165226:849:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/colin-baigent-statins-3.mp4?CAMEFROM=podcastsRSS Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ndm,clinical medicine,epidemiology,cholesterol,statin Colin Baigent 103 356 Mon, 18 Jun 2012 16:52:26 +0100 Translational Medicine tuberculosis vaccine immunisation clinical trial developing world Jenner Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Dr Helen Fletcher works on multi-partner projects to discover biomarkers of protection from TB disease, develop clinical trials capacity in Africa, and develop new vaccines for TB. Dr Fletcher has also developed her own research programme on transcriptional profiling of immune responses following both TB and malaria vaccination. http://rss.oucs.ox.ac.uk/tag:2012-06-12:103216:206:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/helen_fletcher.mp4?CAMEFROM=podcastsRSS Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Dr Helen Fletcher works on multi-partner projects to discover biomarkers of protection from TB disease, develop clinical trials capacity in Africa, and develop new vaccines for TB. Dr Fletcher has also developed her own research programme on transcriptional profiling of immune responses following both TB and malaria vaccination. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ tuberculosis,vaccine,immunisation,clinical trial,developing world,Jenner Helen Fletcher 103 334 Tue, 12 Jun 2012 10:32:16 +0100 Translational Medicine Structural Genomics DNA repair cancer Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. Dr Opher Gileadi studies the structure and chemical biology of proteins involved in DNA repair and in recovery from DNA damage. DNA damage can be both a cause of cancer and a tool in fighting cancer, and the work aims to uncover ways to better target and destroy cancer cells. http://rss.oucs.ox.ac.uk/tag:2012-06-01:151004:871:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/opher_gileadi.mp4?CAMEFROM=podcastsRSS Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. Dr Opher Gileadi studies the structure and chemical biology of proteins involved in DNA repair and in recovery from DNA damage. DNA damage can be both a cause of cancer and a tool in fighting cancer, and the work aims to uncover ways to better target and destroy cancer cells. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Structural Genomics,DNA repair,cancer Opher Gileadi 103 385 Fri, 01 Jun 2012 15:10:04 +0100 Translational Medicine Dengue immunopathology innate immune response vaccine Dr Kerstin Luhn talks about her research on Dengue infection Dr Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam. http://rss.oucs.ox.ac.uk/tag:2012-05-29:133622:944:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/kerstin_luhn.mp4?CAMEFROM=podcastsRSS Dr Kerstin Luhn talks about her research on Dengue infection Dr Kerstin Luhn talks about her research on Dengue infection Dr Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam. Dengue,immunopathology,innate immune response,vaccine Kerstin Luhn 103 318 Tue, 29 May 2012 13:36:22 +0100 Translational Medicine HIV-1 vaccine T cell immune response clinical trials Professor Tomas Hanke tells us about his research on HIV vaccine development. The long term aim for Professor Tomáš Hanke is to develop a safe, effective and accessible HIV-1 vaccine. His group tests novel ideas and vaccine strategies, and focusses on a safe but rapid translation of the most promising laboratory results to phase I/II clinical trials in human volunteers. http://rss.oucs.ox.ac.uk/tag:2012-05-22:150827:049:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/38_tomas_hanke.mp4?CAMEFROM=podcastsRSS Professor Tomas Hanke tells us about his research on HIV vaccine development. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Tomas Hanke tells us about his research on HIV vaccine development. The long term aim for Professor Tomáš Hanke is to develop a safe, effective and accessible HIV-1 vaccine. His group tests novel ideas and vaccine strategies, and focusses on a safe but rapid translation of the most promising laboratory results to phase I/II clinical trials in human volunteers. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV-1,vaccine,T cell,immune response,clinical trials Tomas Hanke 103 348 Tue, 22 May 2012 15:08:27 +0100 Translational Medicine diabetes type-2 personalised treatment clinical trials Professor Stephen Gough talks about the development of personalised diabetes treatment. Prof. Stephen Gough believes that you cannot give every patient affected by diabetes the same treatment; where people react differently to treatments provides a background to his research. Prof. Gough aims to provide the right treatment to the right person at the right time in their disease for optimum results. http://rss.oucs.ox.ac.uk/tag:2012-05-17:141922:835:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/37_stephen_gough.mp4?CAMEFROM=podcastsRSS Professor Stephen Gough talks about the development of personalised diabetes treatment. Professor Stephen Gough talks about the development of personalised diabetes treatment. Prof. Stephen Gough believes that you cannot give every patient affected by diabetes the same treatment; where people react differently to treatments provides a background to his research. Prof. Gough aims to provide the right treatment to the right person at the right time in their disease for optimum results. diabetes,type-2,personalised treatment,clinical trials Stephen Gough 103 343 Thu, 17 May 2012 14:19:22 +0100 Translational Medicine statistical genetics population genetics mutations Professor Gil McVean tells us how statistical genetics helps us understand and treat disease. Prof Gil McVean is the Head of Bioinformatics and Statistical Genetics at the Wellcome Trust Centre for Human Genetics. His research covers several areas in the analysis of genetic variation, combining the development of methods for analysing high throughput sequencing data, theoretical work and empirical analysis. http://rss.oucs.ox.ac.uk/tag:2012-05-17:141203:896:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/36_gil_mcvean.mp4?CAMEFROM=podcastsRSS Professor Gil McVean tells us how statistical genetics helps us understand and treat disease. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Gil McVean tells us how statistical genetics helps us understand and treat disease. Prof Gil McVean is the Head of Bioinformatics and Statistical Genetics at the Wellcome Trust Centre for Human Genetics. His research covers several areas in the analysis of genetic variation, combining the development of methods for analysing high throughput sequencing data, theoretical work and empirical analysis. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ statistical genetics,population genetics,mutations Gil McVean 103 444 Thu, 17 May 2012 14:12:03 +0100 Translational Medicine liver fat liver disease diabetes obesity Dr Leanne Hodson talks about her research on liver fat metabolism. Dr Leanne Hodson's research focuses on fatty liver disease, defined as having over 5 percent liver fat, and a 'silent disease' as many people are not diagnosed. Dr Hodson aims to find targets for new medications which will help lower the risk of accumulating liver fat. http://rss.oucs.ox.ac.uk/tag:2012-05-01:111002:658:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/35_leanne_hodson.mp4?CAMEFROM=podcastsRSS Dr Leanne Hodson talks about her research on liver fat metabolism. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Leanne Hodson talks about her research on liver fat metabolism. Dr Leanne Hodson's research focuses on fatty liver disease, defined as having over 5 percent liver fat, and a 'silent disease' as many people are not diagnosed. Dr Hodson aims to find targets for new medications which will help lower the risk of accumulating liver fat. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ liver fat,liver disease,diabetes,obesity Leanne Hodson 103 448 Tue, 01 May 2012 11:10:02 +0100 Translational Medicine diabetes fat metabolism obesity Dr Barbara Fielding talks about her research on the metabolism of fatty acids. Dr Barbara Fielding believes that nutritional advice should be based on a thorough understanding of metabolic responses to food ingestion, and that it is important to investigate the metabolism of dietary fat after both single and multiple meals, as is customary daily behaviour in Western societies. Ultimately, this will help to make specific dietary recommendations. http://rss.oucs.ox.ac.uk/tag:2012-04-17:120916:214:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/34_barbara_fielding.mp4?CAMEFROM=podcastsRSS Dr Barbara Fielding talks about her research on the metabolism of fatty acids. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Barbara Fielding talks about her research on the metabolism of fatty acids. Dr Barbara Fielding believes that nutritional advice should be based on a thorough understanding of metabolic responses to food ingestion, and that it is important to investigate the metabolism of dietary fat after both single and multiple meals, as is customary daily behaviour in Western societies. Ultimately, this will help to make specific dietary recommendations. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ diabetes,fat metabolism,obesity Barbara Fielding 103 285 Tue, 17 Apr 2012 12:09:16 +0100 Translational Medicine clinical trials meta-analysis epidemiology cardiovascular disease The largest trial investigating the benefits of cholesterol lowering in kidney patients. The Study of Heart and Renal Protection (SHARP) concluded that around a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by using the combination of ezetimibe and simvastatin to lower blood cholesterol levels. http://rss.oucs.ox.ac.uk/tag:2012-04-03:164128:332:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/33_colin_baigent.mp4?CAMEFROM=podcastsRSS The largest trial investigating the benefits of cholesterol lowering in kidney patients. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer The largest trial investigating the benefits of cholesterol lowering in kidney patients. The Study of Heart and Renal Protection (SHARP) concluded that around a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by using the combination of ezetimibe and simvastatin to lower blood cholesterol levels. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ clinical trials,meta-analysis,epidemiology,cardiovascular disease Colin Baigent 103 344 Tue, 03 Apr 2012 16:41:28 +0100 Translational Medicine hepatitis C virus genotype-3 T cells vaccine therapy Dr Ellie Barnes talks about her research on Hepatitis C and her work on a T cell vaccine. Dr Ellie Barnes aims to develop a prophylactic and a therapeutic hepatitis C virus vaccine to combat a global epidemic currently infecting 170 million people worldwide. Many chronically infected patients silently develop complications of liver disease that can include hepatocellular cancer, liver cirrhosis and liver failure. http://rss.oucs.ox.ac.uk/tag:2012-04-03:141142:241:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/32_ellie_barnes.mp4?CAMEFROM=podcastsRSS Dr Ellie Barnes talks about her research on Hepatitis C and her work on a T cell vaccine. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Ellie Barnes talks about her research on Hepatitis C and her work on a T cell vaccine. Dr Ellie Barnes aims to develop a prophylactic and a therapeutic hepatitis C virus vaccine to combat a global epidemic currently infecting 170 million people worldwide. Many chronically infected patients silently develop complications of liver disease that can include hepatocellular cancer, liver cirrhosis and liver failure. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ hepatitis C virus,genotype-3,T cells,vaccine,therapy Ellie Barnes 103 308 Tue, 03 Apr 2012 14:11:42 +0100 Translational Medicine genetics beta-cell dysfunction diabetes glucokinase insulin resistance Dr Anna Gloyn talks about her research on the genetics of Diabetes. The research undertaken by Dr Anna Gloyn focuses on using naturally genetic variants identified in humans as tools to identify critical regulatory pathways for insulin secretion and action. Current research projects are focused on the translation of genetic association signals for type 2 diabetes and glycaemic traits into molecular mechanisms for diabetes and clinically useful tools. http://rss.oucs.ox.ac.uk/tag:2012-03-20:094301:418:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/31_anna_gloyn.mp4?CAMEFROM=podcastsRSS Dr Anna Gloyn talks about her research on the genetics of Diabetes. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Anna Gloyn talks about her research on the genetics of Diabetes. The research undertaken by Dr Anna Gloyn focuses on using naturally genetic variants identified in humans as tools to identify critical regulatory pathways for insulin secretion and action. Current research projects are focused on the translation of genetic association signals for type 2 diabetes and glycaemic traits into molecular mechanisms for diabetes and clinically useful tools. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ genetics,beta-cell dysfunction,diabetes,glucokinase,insulin resistance Anna Gloyn 103 262 Tue, 20 Mar 2012 09:43:01 +0000 Translational Medicine flu HIV hepatitis C hepatitis B emerging infectious disease china Dr Tao Dong tells us about her collaborations in China on infections such as HIV, flu and Hepatitis B. Dr Tao Dong's research interests include antigen-specific T cell responses in human virus infections and their contribution to the consequences of the disease. Hepatitis B virus has recently been added to the list of viruses which Tao and her group studies, which includes influenza and hepatitis C virus/HIV co-infection. http://rss.oucs.ox.ac.uk/tag:2012-03-06:094604:977:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/30_tao_dong.mp4?CAMEFROM=podcastsRSS Dr Tao Dong tells us about her collaborations in China on infections such as HIV, flu and Hepatitis B. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Tao Dong tells us about her collaborations in China on infections such as HIV, flu and Hepatitis B. Dr Tao Dong's research interests include antigen-specific T cell responses in human virus infections and their contribution to the consequences of the disease. Hepatitis B virus has recently been added to the list of viruses which Tao and her group studies, which includes influenza and hepatitis C virus/HIV co-infection. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ flu,HIV,hepatitis C,hepatitis B,emerging infectious disease,china Tao Dong 103 433 Tue, 06 Mar 2012 09:46:04 +0000 Translational Medicine genetics beta-cell dysfunction diabetes glucokinase insulin resistance Prof. Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Prof Arjen Dondorp is the Deputy Director and Head of Malaria Research at the Mahidol-Oxford Tropical Medicine Research Unit in Bangkok, Thailand. His main research interests include the pathophysiology and treatment of severe malaria, antimalarial drug resistance and the improvement of intensive care practice in developing countries. http://rss.oucs.ox.ac.uk/tag:2012-02-21:161047:128:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/29_arjen_dondorp.mp4?CAMEFROM=podcastsRSS Prof. Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Prof. Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Prof Arjen Dondorp is the Deputy Director and Head of Malaria Research at the Mahidol-Oxford Tropical Medicine Research Unit in Bangkok, Thailand. His main research interests include the pathophysiology and treatment of severe malaria, antimalarial drug resistance and the improvement of intensive care practice in developing countries. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ genetics,beta-cell dysfunction,diabetes,glucokinase,insulin resistance Arjen Dondorp 103 488 Tue, 21 Feb 2012 16:10:47 +0000 Translational Medicine HIV-1 HIV-2 T cells immunity infant immunology Africa Professor Sarah Rowland-Jones tells us about her work on HIV with children in Africa. Prof. Sarah Rowland-Jones' work mainly focuses on anti-viral immunity, and in particular how immune responses modify the outcome of HIV infection. Her research aims to contribute to the design of vaccines and immunotherapies against HIV infection, including HIV-2 infection, in developing countries where an effective vaccine is desperately needed. http://rss.oucs.ox.ac.uk/tag:2012-02-07:100720:535:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/27_sarah_rowland-jones.mp4?CAMEFROM=podcastsRSS Professor Sarah Rowland-Jones tells us about her work on HIV with children in Africa. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Sarah Rowland-Jones tells us about her work on HIV with children in Africa. Prof. Sarah Rowland-Jones' work mainly focuses on anti-viral immunity, and in particular how immune responses modify the outcome of HIV infection. Her research aims to contribute to the design of vaccines and immunotherapies against HIV infection, including HIV-2 infection, in developing countries where an effective vaccine is desperately needed. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV-1,HIV-2,T cells,immunity,infant immunology,Africa Sarah Rowland-Jones 103 367 Tue, 07 Feb 2012 10:07:20 +0000 Translational Medicine diabetes calcium exocytosis insulin glucagon and somatostatin Professor Patrik Rorsman talks about Diabetes and how beta cells within the pancreas control insulin secretion. Patrik Rorsman is professor of diabetic medicine in the Oxford Centre for Diabetes, Endocrinology and Metabolism. Professor Rorsman has been at the forefront of research on hormone-secreting cells in the pancreas for more than 20 years, work that is highly relevant to understanding the causes and treatment of type 2 diabetes. The Wellcome Trust award will allow him to study further the metabolic and hormonal regulation of hormone secretion in the pancreas. http://rss.oucs.ox.ac.uk/tag:2012-01-24:093710:021:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/27_patrik_rorsman.mp4?CAMEFROM=podcastsRSS Professor Patrik Rorsman talks about Diabetes and how beta cells within the pancreas control insulin secretion. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Patrik Rorsman talks about Diabetes and how beta cells within the pancreas control insulin secretion. Patrik Rorsman is professor of diabetic medicine in the Oxford Centre for Diabetes, Endocrinology and Metabolism. Professor Rorsman has been at the forefront of research on hormone-secreting cells in the pancreas for more than 20 years, work that is highly relevant to understanding the causes and treatment of type 2 diabetes. The Wellcome Trust award will allow him to study further the metabolic and hormonal regulation of hormone secretion in the pancreas. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ diabetes,calcium,exocytosis,insulin,glucagon and somatostatin Patrik Rorsman 103 463 Tue, 24 Jan 2012 09:37:10 +0000 Translational Medicine HIV T cells vaccine clinical trial viral vector antiretroviral Dr Lucy Dorrell tells us how our immune system controls HIV and how we can live with this virus. The aim of Dr Lucy Dorrells' research is to develop immunotherapy to reduce the dependence of those infected with HIV-1 on their current treatment - antiretroviral therapy (ART). This is because 9 million of the estimated 33 million people living with HIV/AIDS today are not able to access the ARTs which they are in immediate need of. http://rss.oucs.ox.ac.uk/tag:2012-01-10:093033:414:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/26_lucy_dorrell.mp4?CAMEFROM=podcastsRSS Dr Lucy Dorrell tells us how our immune system controls HIV and how we can live with this virus. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Lucy Dorrell tells us how our immune system controls HIV and how we can live with this virus. The aim of Dr Lucy Dorrells' research is to develop immunotherapy to reduce the dependence of those infected with HIV-1 on their current treatment - antiretroviral therapy (ART). This is because 9 million of the estimated 33 million people living with HIV/AIDS today are not able to access the ARTs which they are in immediate need of. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV,T cells,vaccine,clinical trial,viral vector,antiretroviral Lucy Dorrell 103 219 Tue, 10 Jan 2012 09:30:33 +0000 Translational Medicine Hepatitis C virus HIV T cells virus liver and flow cytometry Professor Paul Klenerman talks about our relationship with persistent viruses, such as Hepatitis C. Prof. Paul Klenerman studies the evolutionary relationships between persistent viruses and their human hosts. He aims to understand the role of our immune responses in determining the outcome of Hepatitis C virus infection. Hepatitis C virus infects around 200 million people worldwide and is a major cause of liver disease. http://rss.oucs.ox.ac.uk/tag:2011-12-12:165952:678:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/25_paul_klenerman.mp4?CAMEFROM=podcastsRSS Professor Paul Klenerman talks about our relationship with persistent viruses, such as Hepatitis C. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Paul Klenerman talks about our relationship with persistent viruses, such as Hepatitis C. Prof. Paul Klenerman studies the evolutionary relationships between persistent viruses and their human hosts. He aims to understand the role of our immune responses in determining the outcome of Hepatitis C virus infection. Hepatitis C virus infects around 200 million people worldwide and is a major cause of liver disease. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Hepatitis C virus,HIV,T cells,virus,liver and flow cytometry Paul Klenerman 103 274 Mon, 12 Dec 2011 16:59:52 +0000 Translational Medicine Global health human genome malaria network epidemiology Professor Dominic Kwiatkowski talks about his work on global health, how genomics can help us fight infections such as malaria. Prof. Dominic Kwiatkowski aims to reduce the burden of infectious disease in the developing world. He translates advances in genome science into clinical and epidemiological applications. He mostly works on malaria but many of his tools and methodologies in genetics, statistics, informatics and ethics have applications for other diseases. http://rss.oucs.ox.ac.uk/tag:2011-11-24:135624:632:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/24_dominic_kwiatkowski.mp4?CAMEFROM=podcastsRSS Professor Dominic Kwiatkowski talks about his work on global health, how genomics can help us fight infections such as malaria. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Dominic Kwiatkowski talks about his work on global health, how genomics can help us fight infections such as malaria. Prof. Dominic Kwiatkowski aims to reduce the burden of infectious disease in the developing world. He translates advances in genome science into clinical and epidemiological applications. He mostly works on malaria but many of his tools and methodologies in genetics, statistics, informatics and ethics have applications for other diseases. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Global health,human genome,malaria,network,epidemiology Dominic Kwiatkowski 103 349 Thu, 24 Nov 2011 13:56:24 +0000 Translational Medicine Genetics specific language impairment cognition association study Dr Dianne Newbury talks about the contribution of genetics to specific language impairment. Dr Dianne Newbury is looking for the genes that predispose to Specific Language Impairment, a complex genetic disorder. Two regions, located on chromosomes 16 and 19, are linked with this disorder. Interactions between several normal genetic variants and environmental factors make certain individuals more vulnerable to language problems. http://rss.oucs.ox.ac.uk/tag:2011-11-14:142733:466:clmed/translational-video http://media.podcasts.ox.ac.uk/clmed/translational/23_dianne_newbury.mp4?CAMEFROM=podcastsRSS Dr Dianne Newbury talks about the contribution of genetics to specific language impairment. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Dianne Newbury talks about the contribution of genetics to specific language impairment. Dr Dianne Newbury is looking for the genes that predispose to Specific Language Impairment, a complex genetic disorder. Two regions, located on chromosomes 16 and 19, are linked with this disorder. Interactions between several normal genetic variants and environmental factors make certain individuals more vulnerable to language problems. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Genetics,specific language impairment,cognition,association study Dianne Newbury 103 242 Mon, 14 Nov 2011 14:27:33 +0000 Translational Medicine HIV immune response innate response protective immunity Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. She is also exploring the possibility of harnessing innate immune responses to combat HIV. http://rss.oucs.ox.ac.uk/tag:2011-11-01:094306:617:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/22_seph_borrow.mp4?CAMEFROM=podcastsRSS Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. She is also exploring the possibility of harnessing innate immune responses to combat HIV. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV,immune response,innate response,protective immunity Seph Borrow 103 476 Tue, 01 Nov 2011 09:43:06 +0000 Translational Medicine Physiology oxygen hydroxylase HIF tumour ischaemia and angiogenesis Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. The kidney plays a central role in our metabolism, by controlling various physiological balances. Genetics plays an important role in renal disease since gene defects lead to all sorts of malfunctions. Prof. Chris Pugh is working on the oxygen sensing functions of the body; whilst these were discovered in the context of erythropoietin production the underlying system controls about 1000 genes. http://rss.oucs.ox.ac.uk/tag:2011-10-11:105200:609:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/21_chris_pugh.mp4?CAMEFROM=podcastsRSS Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. The kidney plays a central role in our metabolism, by controlling various physiological balances. Genetics plays an important role in renal disease since gene defects lead to all sorts of malfunctions. Prof. Chris Pugh is working on the oxygen sensing functions of the body; whilst these were discovered in the context of erythropoietin production the underlying system controls about 1000 genes. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Physiology,oxygen,hydroxylase,HIF,tumour,ischaemia and angiogenesis Chris Pugh 103 421 Tue, 11 Oct 2011 10:52:00 +0100 Translational Medicine Genetics dyslexia cognition association study Dr Silvia Paracchini talks about the influence of Genetics in Dyslexia. Dr Silvia Paracchini aims to indentify the genetic components of dyslexia and understand the underlying biology. Other disorders such as Specific Language Impairment or Attention Deficit Hyperactivity Disorder are commonly linked to dyslexia. Dr Paracchini is looking for possible common genes for these clinically distinct disorders. Her research has the potential to uncover some of the biological mechanisms involved in human cognition. http://rss.oucs.ox.ac.uk/tag:2011-09-27:151416:251:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/20_silvia_paracchini.mp4?CAMEFROM=podcastsRSS Dr Silvia Paracchini talks about the influence of Genetics in Dyslexia. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Silvia Paracchini talks about the influence of Genetics in Dyslexia. Dr Silvia Paracchini aims to indentify the genetic components of dyslexia and understand the underlying biology. Other disorders such as Specific Language Impairment or Attention Deficit Hyperactivity Disorder are commonly linked to dyslexia. Dr Paracchini is looking for possible common genes for these clinically distinct disorders. Her research has the potential to uncover some of the biological mechanisms involved in human cognition. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Genetics,dyslexia,cognition,association study Silvia Paracchini 103 425 Tue, 27 Sep 2011 15:14:16 +0100 Translational Medicine HIV vaccines T cell immunity Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Prof. Sir Andrew McMichael is working on human immunology and vaccines, first looking at flu virus and now HIV. His current lines of research include analysing early molecular events in HIV infection, T cell immune response to HIV and the use of vaccination to control HIV infection. http://rss.oucs.ox.ac.uk/tag:2011-09-13:092118:037:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/19_andrew_mcmichael.mp4?CAMEFROM=podcastsRSS Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Prof. Sir Andrew McMichael is working on human immunology and vaccines, first looking at flu virus and now HIV. His current lines of research include analysing early molecular events in HIV infection, T cell immune response to HIV and the use of vaccination to control HIV infection. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ HIV,vaccines,T cell immunity Andrew McMichael 103 415 Tue, 13 Sep 2011 09:21:18 +0100 Translational Medicine Palliative cave end of life care symptom management fatigue Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Dr Bee Wee is the Head of Palliative Care Research and Development, based at Sir Michael Sobell House in Oxford. Her current lines of research include End of life care for people with incurable cancer and advanced non-malignant disease, Symptom management and Rehabilitation. http://rss.oucs.ox.ac.uk/tag:2011-08-30:094722:001:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/18_bee_wee.mp4?CAMEFROM=podcastsRSS Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Dr Bee Wee is the Head of Palliative Care Research and Development, based at Sir Michael Sobell House in Oxford. Her current lines of research include End of life care for people with incurable cancer and advanced non-malignant disease, Symptom management and Rehabilitation. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Palliative cave,end of life care,symptom management,fatigue Bee Wee 103 301 Tue, 30 Aug 2011 09:47:22 +0100 Translational Medicine Global health malaria immunology epidemiology Professor Kevin Marsh tells us about his research on Tropical Medicine in Kenya. Prof. Kevin Marsh has a broad research interest in child health in the tropics, with a particular focus in the immune epidemiology of malaria. Prof. Marsh is director of the KEMRI Wellcome Programme in Kenya; he also coordinates the malaria immunology group within the programme. http://rss.oucs.ox.ac.uk/tag:2011-07-19:094804:277:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/17_kevin_marsh.mp4?CAMEFROM=podcastsRSS Professor Kevin Marsh tells us about his research on Tropical Medicine in Kenya. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Kevin Marsh tells us about his research on Tropical Medicine in Kenya. Prof. Kevin Marsh has a broad research interest in child health in the tropics, with a particular focus in the immune epidemiology of malaria. Prof. Marsh is director of the KEMRI Wellcome Programme in Kenya; he also coordinates the malaria immunology group within the programme. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Global health,malaria,immunology,epidemiology Kevin Marsh 103 237 Tue, 19 Jul 2011 09:48:04 +0100 Translational Medicine Structural biology tumour immunology signalling complexes x-ray crystallography protein-protein interaction Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Prof. Yvonne Jones is director of the Cancer Research UK Receptor Structure Research Group. Her research focuses on the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer. http://rss.oucs.ox.ac.uk/tag:2011-07-06:113554:148:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/16_yvonne_jones.mp4?CAMEFROM=podcastsRSS Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Prof. Yvonne Jones is director of the Cancer Research UK Receptor Structure Research Group. Her research focuses on the structural biology of cell surface recognition and signalling complexes. Receptors embedded in the surface are potential targets for therapeutic intervention in many diseases including cancer. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Structural biology,tumour immunology,signalling complexes,x-ray crystallography,protein-protein interaction Yvonne Jones 103 348 Wed, 06 Jul 2011 11:35:54 +0100 Translational Medicine integrative physiology obesity human metabolism type 2 diabetes biobanks genetic epidemiology Professor Fredrik Karpe explores the links between obesity and diabetes. Prof. Fredrik Karpe initiated the Oxford Biobank for prospective genetic epidemiological research. Integrative physiological and genomic approaches are used to study lipid and carbohydrate metabolism. Prof. Karpe also studies the links between obesity, insulin resistance, type 2 diabetes and cardiovascular disease. http://rss.oucs.ox.ac.uk/tag:2011-06-21:091854:372:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/15_fredrik_karpe.mp4?CAMEFROM=podcastsRSS Professor Fredrik Karpe explores the links between obesity and diabetes. Professor Fredrik Karpe explores the links between obesity and diabetes. Prof. Fredrik Karpe initiated the Oxford Biobank for prospective genetic epidemiological research. Integrative physiological and genomic approaches are used to study lipid and carbohydrate metabolism. Prof. Karpe also studies the links between obesity, insulin resistance, type 2 diabetes and cardiovascular disease. integrative physiology,obesity,human metabolism,type 2 diabetes,biobanks,genetic epidemiology Fredrik Karpe 103 336 Tue, 21 Jun 2011 09:18:54 +0100 Translational Medicine proteomics ubiquitin HIV immunology infectious diseases biomarkers Dr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination. Alterations in this process are responsible for many human diseases. Dr Benedikt Kessler studies the role of deubiquitylating enzymes that remove ubiquitin from substrate proteins. http://rss.oucs.ox.ac.uk/tag:2011-06-07:094649:205:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/14_benedikt_kessler.mp4?CAMEFROM=podcastsRSS Dr Benedikt Kessler tells us how proteomics helps find biomarkers. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination. Alterations in this process are responsible for many human diseases. Dr Benedikt Kessler studies the role of deubiquitylating enzymes that remove ubiquitin from substrate proteins. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ proteomics,ubiquitin,HIV,immunology,infectious diseases,biomarkers Benedikt Kessler 103 512 Tue, 07 Jun 2011 09:46:49 +0100 Translational Medicine innate immunity signalling HIV Crohn's disease Dr Alison Simmons tells us about her work on Crohns disease, an inflammatory bowel disease. Dr Alison Simmons is interested in the molecular aspects of innate immune recognition, the primitive arm of the immune system that defends the host from infection by other organisms in a non-specific manner. Defects in the innate immune system can result in difficulty clearing infections but also in inflammation. http://rss.oucs.ox.ac.uk/tag:2011-05-23:110302:830:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/13_alison_simmons.mp4?CAMEFROM=podcastsRSS Dr Alison Simmons tells us about her work on Crohns disease, an inflammatory bowel disease. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Alison Simmons tells us about her work on Crohns disease, an inflammatory bowel disease. Dr Alison Simmons is interested in the molecular aspects of innate immune recognition, the primitive arm of the immune system that defends the host from infection by other organisms in a non-specific manner. Defects in the innate immune system can result in difficulty clearing infections but also in inflammation. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ innate immunity,signalling,HIV,Crohn's disease Alison Simmons 103 344 Mon, 23 May 2011 11:03:02 +0100 Translational Medicine cancer epidemiology nutrition hormones diet Professor Tim Key tells us about the role of life style and diet in the development of cancer. Prof. Tim Key is interested in the role of diet and hormones in the development of cancer, particularly cancers of the breast, prostate and bowel. Prof. Key is the principal investigator of the EPIC-Oxford cohort of sixty thousand participants, for various studies on cancer, hormones and nutrition. http://rss.oucs.ox.ac.uk/tag:2011-05-10:092023:982:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/12_tim_key.mp4?CAMEFROM=podcastsRSS Professor Tim Key tells us about the role of life style and diet in the development of cancer. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Tim Key tells us about the role of life style and diet in the development of cancer. Prof. Tim Key is interested in the role of diet and hormones in the development of cancer, particularly cancers of the breast, prostate and bowel. Prof. Key is the principal investigator of the EPIC-Oxford cohort of sixty thousand participants, for various studies on cancer, hormones and nutrition. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ cancer,epidemiology,nutrition,hormones,diet Tim Key 103 271 Tue, 10 May 2011 09:20:23 +0100 Translational Medicine autophagy cell death tumour immunity tolerance Dr Katja Simon tells us about her research on autophagy in red blood cells. Autophagy is the cellular process in which cells degrade their toxic waste and damaged organelles. Dr Katja Simon studies how the lack of autophagy seems to trigger DNA mutations and the development of leukemic cells. This might help us make better use of current therapies and develop new ones. http://rss.oucs.ox.ac.uk/tag:2011-04-26:093517:799:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/11_katja_simon.mp4?CAMEFROM=podcastsRSS Dr Katja Simon tells us about her research on autophagy in red blood cells. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Katja Simon tells us about her research on autophagy in red blood cells. Autophagy is the cellular process in which cells degrade their toxic waste and damaged organelles. Dr Katja Simon studies how the lack of autophagy seems to trigger DNA mutations and the development of leukemic cells. This might help us make better use of current therapies and develop new ones. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ autophagy,cell death,tumour immunity,tolerance Katja Simon 103 326 Tue, 26 Apr 2011 09:35:17 +0100 Translational Medicine spondyloarthritis immunology lymphocytes ankylosing spondylitis Dr Paul Bowness tells us about his work on spondyloarthritis. Dr Paul Bownessis works on Ankylosing Spondylitis, the commonest form of spondyloarthritis. This rheumatic disease seems to be caused by an overacting immune system. It has a major genetic component: at least 5-10 genes are known to contribute the disease, with HLA-B27 being by far the most important. Dr Bowness studies how these genes work in the immune systems of both healthy people and patients with arthritis. http://rss.oucs.ox.ac.uk/tag:2011-04-12:103536:831:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/10_paul_bowness.mp4?CAMEFROM=podcastsRSS Dr Paul Bowness tells us about his work on spondyloarthritis. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Paul Bowness tells us about his work on spondyloarthritis. Dr Paul Bownessis works on Ankylosing Spondylitis, the commonest form of spondyloarthritis. This rheumatic disease seems to be caused by an overacting immune system. It has a major genetic component: at least 5-10 genes are known to contribute the disease, with HLA-B27 being by far the most important. Dr Bowness studies how these genes work in the immune systems of both healthy people and patients with arthritis. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ spondyloarthritis,immunology,lymphocytes,ankylosing spondylitis Paul Bowness 103 278 Tue, 12 Apr 2011 10:35:36 +0100 Translational Medicine obesity fat distribution meta-analysis genetic association gene expression Dr Cecilia Lindgren explores the links between obesity and genetics. Obesity and its consequences are major and growing challenges for health care worldwide. Over 30 genes associated with body mass index have now been identified. Dr Cecilia Lindgren uses genetic and genomic approaches to better understand the underlying mechanisms and pathways involved in the regulation of overall energy balance. http://rss.oucs.ox.ac.uk/tag:2011-03-29:100244:941:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/09_cecilia_lindgren.mp4?CAMEFROM=podcastsRSS Dr Cecilia Lindgren explores the links between obesity and genetics. Dr Cecilia Lindgren explores the links between obesity and genetics. Obesity and its consequences are major and growing challenges for health care worldwide. Over 30 genes associated with body mass index have now been identified. Dr Cecilia Lindgren uses genetic and genomic approaches to better understand the underlying mechanisms and pathways involved in the regulation of overall energy balance. obesity,fat distribution,meta-analysis,genetic association,gene expression Cecilia Lindgren 103 483 Tue, 29 Mar 2011 10:02:44 +0100 Translational Medicine iron hepcidin malaria ferroportin HIV hepatitis C immune system infection Dr Hal Drakesmith tells us how his work on iron availability can help us fight infections. Iron plays essential biochemical roles in oxygen binding, ATP synthesis and DNA metabolism. The level of iron available in different tissues is controlled by the small peptide hormone hepcidin. Dr Hal Drakesmith studies how hepcidin is modulated during infections, since iron availability plays an important role in the course of major infectious diseases such as HIV, malaria and Hepatitis C. Genetic variation plays an important role in individual susceptibility to many common diseases. New insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases. We can then target treatments much more effectively. Ultimately, we will be able to identify patients at risk of developing disease. http://rss.oucs.ox.ac.uk/tag:2011-03-15:114713:745:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/08_hal_drakesmith.mp4?CAMEFROM=podcastsRSS Dr Hal Drakesmith tells us how his work on iron availability can help us fight infections. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Hal Drakesmith tells us how his work on iron availability can help us fight infections. Iron plays essential biochemical roles in oxygen binding, ATP synthesis and DNA metabolism. The level of iron available in different tissues is controlled by the small peptide hormone hepcidin. Dr Hal Drakesmith studies how hepcidin is modulated during infections, since iron availability plays an important role in the course of major infectious diseases such as HIV, malaria and Hepatitis C. Genetic variation plays an important role in individual susceptibility to many common diseases. New insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases. We can then target treatments much more effectively. Ultimately, we will be able to identify patients at risk of developing disease. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ iron,hepcidin,malaria,ferroportin,HIV,hepatitis C,immune system,infection Hal Drakesmith 103 496 Tue, 15 Mar 2011 11:47:13 +0000 Translational Medicine medicine tuberculosis vaccine immunisation clinical trial developing world jenner Dr Helen McShane has been working on a new TB vaccine for 10 years. She explains why developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. Dr Helen McShane developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. BCG, now over 100 years old, remains the only licensed vaccine against Tuberculosis. It confers good protection against severe disease and meningitis but doesn't protect against lung disease. MVA85A was the first vaccine of the new generation to enter into efficacy testing. It is currently being tested in The Gambia, Senegal and South Africa. http://rss.oucs.ox.ac.uk/tag:2011-03-01:133759:138:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/07_helen_mcshane.mp4?CAMEFROM=podcastsRSS Dr Helen McShane has been working on a new TB vaccine for 10 years. She explains why developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Helen McShane has been working on a new TB vaccine for 10 years. She explains why developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. Dr Helen McShane developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. BCG, now over 100 years old, remains the only licensed vaccine against Tuberculosis. It confers good protection against severe disease and meningitis but doesn't protect against lung disease. MVA85A was the first vaccine of the new generation to enter into efficacy testing. It is currently being tested in The Gambia, Senegal and South Africa. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ medicine,tuberculosis,vaccine,immunisation,clinical trial,developing world,jenner Helen McShane 103 233 Tue, 01 Mar 2011 13:37:59 +0000 Translational Medicine medicine target validation drug discovery disease structural biology Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have allowed him to progress promising clinical candidates into Phase I, II, III studies, and to market. Drug candidates are first selected by screening compounds capable of binding to a target protein. Those compounds are then tested in various assay systems, healthy volunteers and finally in patients. Academic research excels at defining good target proteins. Pharmaceutical companies then facilitate the transition from basic research to clinical trials, producing new therapies for patients. http://rss.oucs.ox.ac.uk/tag:2010-12-20:150515:896:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/06_chas_bountra.mp4?CAMEFROM=podcastsRSS Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have allowed him to progress promising clinical candidates into Phase I, II, III studies, and to market. Drug candidates are first selected by screening compounds capable of binding to a target protein. Those compounds are then tested in various assay systems, healthy volunteers and finally in patients. Academic research excels at defining good target proteins. Pharmaceutical companies then facilitate the transition from basic research to clinical trials, producing new therapies for patients. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ medicine,target validation,drug discovery,disease,structural biology Chas Bountra 103 340 Mon, 20 Dec 2010 15:05:15 +0000 Translational Medicine medicine disease immunity inflammation autoimmune diseases genetics gene Dr Julian Knight explains how new insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases, and allow us to target treatments more effectively. Dr Julian Knight studies how genetic variation between individuals affect the way immune and inflammatory genes are expressed. This helps understand genetic susceptibility to common conditions such as infectious, inflammatory or autoimmune diseases. He recently published a book titled 'Human Genetic Diversity, functional consequences for health and disease'. Genetic variation plays an important role in individual susceptibility to many common diseases. http://rss.oucs.ox.ac.uk/tag:2010-11-29:113600:637:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/05_julian_knight.mp4?CAMEFROM=podcastsRSS Dr Julian Knight explains how new insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases, and allow us to target treatments more effectively. Dr Julian Knight explains how new insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases, and allow us to target treatments more effectively. Dr Julian Knight studies how genetic variation between individuals affect the way immune and inflammatory genes are expressed. This helps understand genetic susceptibility to common conditions such as infectious, inflammatory or autoimmune diseases. He recently published a book titled 'Human Genetic Diversity, functional consequences for health and disease'. Genetic variation plays an important role in individual susceptibility to many common diseases. medicine,disease,immunity,inflammation,autoimmune diseases,genetics,gene Julian Knight 103 330 Mon, 29 Nov 2010 11:35:18 +0000 Translational Medicine medicine disease chromatin remodelling transcription regulation leukemia heart diseases gene Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Dr Erika Mancini is interested in the role of chromatin in the regulation of gene transcription. All our cells contain the same set of genes, but only some of them are transcribed at any point in a particular tissue. Regulation of gene transcription is strongly linked to chromatin, physical packaging of the DNA within the nucleus. Molecular Mechanisms influencing DNA packaging Chromatin plays an important role in the regulation of gene expression. The movement of nucleosomes, packing and unpacking DNA, is governed by chromatin remodelling ATPases. Malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. http://rss.oucs.ox.ac.uk/tag:2010-11-15:105139:580:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/04_erika_mancini.mp4?CAMEFROM=podcastsRSS Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Dr Erika Mancini is interested in the role of chromatin in the regulation of gene transcription. All our cells contain the same set of genes, but only some of them are transcribed at any point in a particular tissue. Regulation of gene transcription is strongly linked to chromatin, physical packaging of the DNA within the nucleus. Molecular Mechanisms influencing DNA packaging Chromatin plays an important role in the regulation of gene expression. The movement of nucleosomes, packing and unpacking DNA, is governed by chromatin remodelling ATPases. Malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ medicine,disease,chromatin remodelling,transcription regulation,leukemia,heart diseases,gene Erika Mancini 103 311 Mon, 15 Nov 2010 10:51:39 +0000 Translational Medicine tropical diseases medicine malaria africa developing world Dr Climent Casals-Pascual explains how the development of new tools to diagnose and manage malaria more effectively will allow us to decrease the mortality of this condition. Dr Climent Casals-Pascual is interested in severe malaria, particularly its diagnosis and clinical management. Clinical symptoms of severe malaria are similar to those of other diseases like pneumonia and meningitis. In tropical countries, poor diagnosis often results in sub-optimal treatments. Integrating proteomic, genomic and clinical data will help us explain differences in clinical outcome in severe malaria. http://rss.oucs.ox.ac.uk/tag:2010-11-02:103103:383:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/03_climent_casals-pascual.mp4?CAMEFROM=podcastsRSS Dr Climent Casals-Pascual explains how the development of new tools to diagnose and manage malaria more effectively will allow us to decrease the mortality of this condition. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Dr Climent Casals-Pascual explains how the development of new tools to diagnose and manage malaria more effectively will allow us to decrease the mortality of this condition. Dr Climent Casals-Pascual is interested in severe malaria, particularly its diagnosis and clinical management. Clinical symptoms of severe malaria are similar to those of other diseases like pneumonia and meningitis. In tropical countries, poor diagnosis often results in sub-optimal treatments. Integrating proteomic, genomic and clinical data will help us explain differences in clinical outcome in severe malaria. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ tropical diseases,medicine,malaria,africa,developing world Climent Casals-Pascual 103 478 Tue, 02 Nov 2010 10:31:03 +0000 Translational Medicine tropical diseases vaccines malaria africa developing world jenner Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Professor Hill develops vaccines against malaria based on inducing cellular immune responses (T lymphocytes) instead of the more commonly used stimulation of antibodies. Prophylactic vaccines developed in Oxford are now showing great promise in clinical trials. http://rss.oucs.ox.ac.uk/tag:2010-10-18:145912:424:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/02_adrian_hill.mp4?CAMEFROM=podcastsRSS Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ ukoer Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Professor Hill develops vaccines against malaria based on inducing cellular immune responses (T lymphocytes) instead of the more commonly used stimulation of antibodies. Prophylactic vaccines developed in Oxford are now showing great promise in clinical trials. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ tropical diseases,vaccines,malaria,africa,developing world,jenner Adrian Hill 103 339 Mon, 18 Oct 2010 14:58:35 +0100 Translational Medicine endometriosis epidemiology infertility women's health genetics pelvic pain Dr Krina Zondervan is interested is women's health conditions, particularly endometriosis. Dr Zondervan studies genetic, molecular and environmental factors influencing this complex disorder. Women suffering from endometriosis experience severe pelvic pain and may suffer from infertility. Endometrial-like cells develop outside the uterine cavity. These cells are influenced by hormonal changes and respond similarly as the cells lining the uterus. Causes of endometriosis remain unknown and treatments are limited to either surgery or the use of hormonal drugs. http://rss.oucs.ox.ac.uk/tag:2010-09-30:172959:443:medsci/ndm-translational-vide http://media.podcasts.ox.ac.uk/clmed/translational/01_krina_zondervan.mp4?CAMEFROM=podcastsRSS Dr Krina Zondervan is interested is women's health conditions, particularly endometriosis. Dr Zondervan studies genetic, molecular and environmental factors influencing this complex disorder. Dr Krina Zondervan is interested is women's health conditions, particularly endometriosis. Dr Zondervan studies genetic, molecular and environmental factors influencing this complex disorder. Women suffering from endometriosis experience severe pelvic pain and may suffer from infertility. Endometrial-like cells develop outside the uterine cavity. These cells are influenced by hormonal changes and respond similarly as the cells lining the uterus. Causes of endometriosis remain unknown and treatments are limited to either surgery or the use of hormonal drugs. endometriosis,epidemiology,infertility,women's health,genetics,pelvic pain Krina Zondervan 103 405 Thu, 30 Sep 2010 17:29:59 +0100 Translational Medicine