Biochemistry Seminars

What Structural Dissection of Bacterial Flagellar Motors In Situ tell us about Structure and Function

undisclosed_email_address@ox.ac.uk (OUBS) — Thu, 16 May 2013 11:36:38 +0100

What Structural Dissection of Bacterial Flagellar Motors In Situ tell us about Structure and Function What Structural Dissection of Bacterial Flagellar Motors In Situ tell us about Structure and Function Dr. Morgan Beeby 3 June from 16:00 to 17:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

Regulation of translation by ribosome hydroxylation in eukaryotes

undisclosed_email_address@ox.ac.uk (OUBS) — Wed, 08 May 2013 13:47:52 +0100

Regulation of translation by ribosome hydroxylation in eukaryotes Regulation of translation by ribosome hydroxylation in eukaryotes Dr Christoph Loenarz 20 May from 16:00 to 17:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

LMB seminar:

undisclosed_email_address@ox.ac.uk (Sylvia McLain) — Fri, 03 May 2013 17:19:20 +0100

LMB seminar: LMB seminar LMB seminar: Sebastian Busch 24 May from 12:30 to 13:30 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

"Robustness of developmental patterns in C. elegans"

undisclosed_email_address@ox.ac.uk (Sarah-Jane Scard) — Wed, 01 May 2013 16:19:16 +0100

"Robustness of developmental patterns in C. elegans" Special Seminar "Robustness of developmental patterns in C. elegans" Dr. Michalis Barkoulas Institute of Biology of the Ecole Normale Superieure (IBENS), France 3 June from 11:00 to 12:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

head@bioch.ox.ac.uk 01865 613212

OCISB Seminar: Sensitivity and Robustness in Bifunctional Enzyme Systems: Reconciling Ultrasensitivity with Bifunctionality

undisclosed_email_address@ox.ac.uk (Charlotte Smith) — Wed, 01 May 2013 13:27:28 +0100

OCISB Seminar: Sensitivity and Robustness in Bifunctional Enzyme Systems: Reconciling Ultrasensitivity with Bifunctionality OCISB Seminar OCISB Seminar: Sensitivity and Robustness in Bifunctional Enzyme Systems: Reconciling Ultrasensitivity with Bifunctionality Dr Ronny Straube 2 August from 14:00 to 15:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

Biological systems have to operate reliably under changing environmental conditions which makes it necessary that the underlying regulatory networks are robust with respect to some perturbations while remaining sensitive to others. Regulation by covalent modification is a common mechanism to transmit signals in biological systems. Intriguingly, there exist two architectures for this purpose: Either modification and demodification are catalyzed by distinct converter enzymes or both reactions are carried out by a single bifunctional enzyme. Theoretical studies predict that covalent modification cycles with two converter enzymes can exhibit zero-order ultrasensitivity (ZOUS) whereas a bifunctional design of the converter enzyme has been associated with a particular form of robustness called absolute concentration robustness (ACR). However, the first experimental evidence for an enhanced sensitivity due to the zero-order effect actually came from studies with a bifunctional enzyme system raising the question about the underlying mechanism. Here, I show that bifunctional enzymes with two catalytic sites cannot only exhibit ACR, but also ZOUS similarly as CMCs with distinct converter enzymes. Comparison of the theoretical results with experimental observations of ZOUS in the phosphorylation cycle of the isocitrate dehydrogenase and the uridylylation cycle of the PII protein yield remarkable agreement. Together, these results provide a rationale for the experimental observations of ZOUS in bifunctional enzyme systems. They also show how sensitivity and robustness can arise from the same regulatory mechanism.

ALL INVITED bela.novak@bioch.ox.ac.uk

"Cell entry, assembly and evolution of enveloped RNA viruses"

undisclosed_email_address@ox.ac.uk (Sarah-Jane Scard) — Wed, 24 Apr 2013 15:28:05 +0100

"Cell entry, assembly and evolution of enveloped RNA viruses" Special Seminar "Cell entry, assembly and evolution of enveloped RNA viruses" Professor Yorgo Modis Associate Professor, Dept of Molecular Biophysics and Biochemistry, Yale University 20 June from 11:00 to 12:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

head@bioch.ox.ac.uk 13212

"Multi-state modelling of synaptic proteins"

undisclosed_email_address@ox.ac.uk (Sarah-Jane Scard) — Wed, 27 Mar 2013 13:04:11 +0000

"Multi-state modelling of synaptic proteins" Special Seminar "Multi-state modelling of synaptic proteins" Dr. Melanie Stefan California Institute of Technology 13 June from 11:00 to 12:00 Main Meeting Room, New Biochemistry Building, Department of Biochemistry, South Parks Road, Oxford OX1 3QU

head@bioch.ox.ac.uk 01865 613212

TBA

undisclosed_email_address@ox.ac.uk (Julian Jordan) — Fri, 01 Mar 2013 08:04:13 +0000

Eighth Unither Baruch Blumberg Lecture TBA Dr Anthony Fauci Director, National Institute of Allergy and Infectious Diseases, NIH 13 November from 17:30 to 18:30 Headley Lecture Theatre, Ashmolean Museum, Beaumont Street, Oxford OX1 2PH

lynda.butters@bioch.ox.ac.uk 01865 275344 Champagne reception to follow in the Mallett Gallery